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Key Allergens

This was previously called Oral Allergy Syndrome (OAS), the term was coined to define the symptoms. It has now been termed Pollen Food Allergy Syndrome (PFAS) more definitively as it mostly affects people who already suffer from pollen allergies and seasonal rhinitis due to cross reactivity.

In PFAS the body mistakes the shape of a protein that it is already sensitive to (a plant pollen) to a similarly shaped protein in certain fruits, vegetables, spices, herbs, and nuts.

The key allergen in PFAS is the pollen associated with the group of foods you are having symptoms from eating. It is most commonly associated with birch tree pollen, the allergen is called Bet v 1-like proteins.

If you are interested in which foods contain which allergenic proteins you can visit the Food Allergy Tool Page.

You may have Pollen-Food Allergy Syndrome if you suffer from oral allergy symptoms to 3 or more of the foods mentioned in cross reactivity section.

Celery-Mugwort-Spice Syndrome is a sub-category of Pollen Food Allergy Syndrome where profilin proteins are the sensitising proteins.

Cross Reactivity

The main two cross reactive proteins associated with Pollen Food Allergy Syndrome are Profilin and Bet v 1. Below are screenshots from the Cross Reactivity Tool showing which foods contain which allergen.

Foods containing Bet v 1

Table of Cross Reactivity of Bet v 1 Proteins, 2024

Foods containing Profilins

Table of Cross Reactivity Profilin Proteins, 2024

You can read more about any of these foods from the dedicated Food Allergy Index or you can download a Bet v 1 and Pollen Food Allergy Syndrome Factsheet from the Allergy Resources Ko-fi Shop for just $0.50 (£0.40 or €0.45).



Allergy UK - Information and Advice

AAAAI - Oral Allergy Syndrome

Anaphylaxis Campaign

Dermnet NZ - Pollen Food Allergy Syndrome

Patient UK - Oral Allergy Syndrome

Articles and Journals

Allergen Component Testing: Key in Diagnosing Atypical Pollen-Food Allergy Syndrome

Pollen food allergy syndrome secondary to molds and raw mushroom cross-reactivity: a case report, 2024

Diagnosis and Management of Pollen-Food Allergy Syndrome to Nuts, 2024

Carrot-Induced Systemic Reaction: A Unique Presentation of Pollen-Food Allergy Syndrome in a Young Boy, 2023

Cross-reactive food and pollen allergens most commonly involved in oral allergy syndrome in adults with eosinophilic esophagitis, 2023

Anaphylaxis across Europe: are pollen food syndrome and lipid transfer protein allergy so far apart? 2022

BSACI guideline for the diagnosis and management of pollen food syndrome in the U, 2022

Clinical Relevance of Profilin Sensitization Concerning Oral Allergy Syndrome in Birch Pollen Sensitized Patients, 2022

Surveillance of pollen-food allergy syndrome in elementary and junior high school children in Saitama, Japan, 2022

Food allergy in early childhood increases the risk of oral allergy syndrome in schoolchildren: A birth cohort study, 2022

Pollen-food allergy syndrome and component sensitization in adolescents: A Japanese population-based study, 2021

Pollen-related food allergy in children with seasonal allergic rhinitis, 2021

Heterogeneity of Pollen Food Allergy Syndrome in Seven Southern European Countries: the @IT.2020 Multicenter Study, 2021

Molecular approach to a patient’s tailored diagnosis of the oral allergy syndrome, 2020

Insights into pediatric pollen food allergy syndrome, 2020

Food cross-reactivity in patients with pollen allergies, 2020

Pollen-food allergy syndrome in children, 2020

Update on pollen-food allergy syndrome, 2020

Oral Allergy Syndrome, 2010

Let me know if you found any of these interesting or useful. If you spot an article or research that you think is interesting you can message me or tag me on Facebook or Twitter - links at the bottom of the page.

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