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Key Allergens

Pistachio nuts are in the Anacardiaceae family of plants. Other plants in this family include cashew nuts, mango and sumac.

There are 5 allergens in pistachio nuts. Pis v 1, 2, 3, 4 and 5.

Most tree nut allergies are caused by seed storage proteins, pistachios have all 3 types of seed storage protein. Pis v 1 is a 2S seed storage albumin protein.

Pis v 2 and 5 are 11S seed storage globulin proteins, also known as legumin proteins.

Pis v 3 is a vicilin protein, also called a 7S seed storage globulin protein. These seed storage proteins can cause people to be allergic to whole groups of tree nuts, seeds and legumes.

Pis v 4 is a manganese superoxide dismutase which is a plant enzyme.

Food Intolerances

Food is high in FODMAP Food is high in salicylates

Pistachios are high FODMAP food. FODMAP stands for Fermentable oligosaccharides, disaccharides, monosaccharides and polyols. Foods high in FODMAPs can cause symptoms of food intolerance, affecting the gastro intestinal system and this can be mistaken for a true IgE food allergy.

Pistachio nuts are a food high in salicylates. Salicylates have the potential to cause gastrointestinal food intolerance symptoms in people who are sensitive to salicylates.

You can read more about Food Intolerances on the dedicated Food Intolerance Page.

Associated Syndromes

Pistachio allergy is not currently associated with any allergic syndromes.

Cross Reactivity

The most studied cross reactivity is between pistachio and cashew nuts.

Other food containing 2S albumin seed storage proteins are cashews, peanuts, brazil nuts, mustard seed, rapeseed, turnip, chickpeas, hazelnuts, pecan nuts, buckwheat, soya, sunflower seeds, walnuts, kiwi, castor beans and sesame seeds.

Other foods containing 7S seed storage proteins are peanuts, cashews, pecan, hazelnut, soya beans, walnut, macadamia nuts, sesame and lupin all contain 2S seed storage proteins. Fruits and vegetables containing these proteins are coconut, mung beans and peas. 7S seed storage proteins are also found in buckwheat and lentils.

11S seed storage proteins are also found in kiwi, cashew, pecan, macadamia, peanut, brazil nut, pumpkin, soya beans, walnut, pistachio, sesame and mustard.

You can download a Tree Nut Allergy Factsheet from the Allergy Resources Ko-fi Shop for just $0.50 (£0.40 or €0.45). This has up to date information on which foods contain linked allergens and what foods to avoid if you think you have an allergy to tree nuts.

Note that these food lists are not exhaustive, the most up to date information is on the Cross Reactivity Tool.



Allergen Encyclopedia - Pistachio

What Are the Symptoms of a Nut Allergy?

Allergy UK - Tree Nut Allergy Factsheet

FARE - Tree Nut Allergy

Healthline - FODMAP Foods

ATP Science - Salicylate Foods

Articles and Journals

Prevalence of tree nut allergy in Europe: A systematic review and meta-analysis, 2024

Citrin: a novel food allergen in citrus seeds and citrus-derived pectin that shows cross-reactivity with cashew and pistachio, 2023

Pistachio Allergens: The Long Journey Between Mother and Daughter, 2023

Tree nut and peanut allergy in a Portuguese pediatric cohort - clinical characterization and anaphylaxis predictors, 2023

Quantitative In Silico Evaluation of Allergenic Proteins from Anacardium occidentale, Carya illinoinensis, Juglans regia and Pistacia vera and Their Epitopes as Precursors of Bioactive Peptides, 2022

Pistachio and cashew nut allergy in childhood: Predictive factors towards development of a decision tree, 2021

Cross-reactivity of pink peppercorn in cashew and pistachio allergic individuals, 2019

Tree nut allergens, 2018

Current perspectives on tree nut allergy: a review, 2018

Sensitization to cashew nut 2S albumin, Ana o 3, is highly predictive of cashew and pistachio allergy in Greek children, 2015

Cloning, expression, characterization, and computational approach for cross-reactivity prediction of manganese superoxide dismutase allergen from pistachio nut, 2010

Identification of two pistachio allergens, Pis v 1 and Pis v 2, belonging to the 2S albumin and 11S globulin family, 2009

2S Albumin Storage Proteins: What Makes them Food Allergens?, 2008

Pistachio vicilin, Pis v 3, is immunoglobulin E-reactive and cross-reacts with the homologous cashew allergen, Ana o 1, 2008

Let me know if you found any of these interesting or useful. If you spot an article or research that you think is interesting you can message me or tag me on Facebook or Twitter - links at the bottom of the page.

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