Key Allergens

Tomatoes are in the Solanaceae family of plants. Other plants in this family include aubergine (eggplant), peppers, chillis and goji berries. This group of plants are also commonly called 'nightshades'.

There are 7 allergens associated with tomato allergy - the main allergen in tomato is Sola l 4 which is similar in shape to the Bet v 1 allergens which can cause oral allergy type symptoms.

Three of the proteins found in tomato are Lipid Transfer Proteins, (LTPs). These proteins are panallergens with the potential to cause serious allergic reactions.

Sol l 1 is a profilin protein, these proteins are also panallergens and can cause problems across lots of groups of fruit and vegetables.

Tomatoes also contain a plant cyclophilin, which are multi functional proteins.

Food Intolerances

Food is low in FODMAP Food is medium in lectins Food is high in histamine Food is high in sulphites Food is moderate in salicylates

Tomato is a food high in histamine, so is not suitable for people following a low histamine diet.

Tomatoes which have been pickled or preserved, e.g. chutney, tomato puree and ketchup are also high in sulphites, fresh tomatoes contain minimal sulphites. Sulphites are inorganic salts used in preservations and have the potential to cause symptoms of food intolerance to those sensitive to sulphites, this food intolerance is more common in asthmatics. An improvement in symptoms can be made with a change to a low sulphite diet.

Tomatoes are a low FODMAP food. FODMAP stands for Fermentable oligosaccharides, disaccharides, monosaccharides and polyols. Foods high in FODMAPs can cause symptoms of food intolerance, affecting the gastro intestinal system and this can be mistaken for a true IgE food allergy.

Fresh tomatoes are low in salicylates, but being processed or canned increases the amount of salicylates in the product. So tomatoes have the potential to cause gastrointestinal food intolerance symptoms in people who are sensitive to salicylates.

Tomatoes are one of the few vegetables to contain a moderate amount of lectins, another cause of food intolerance. Cooking foods with lectins makes them more digestible and can reduce the symptoms of food intolerance.

You can read more about Food Intolerances on the dedicated Food Intolerance Page.

Associated Syndromes

You may have Pollen-Food Allergy Syndrome if you suffer from tomato allergy with oral allergy symptoms to 3 or more of the foods mentioned in cross reactivity section.

Allergy to tomato is sometimes linked to Celery-Mugwort-Spice Syndrome as the sensitising allergen is a profilin protein called Art v 4, these proteins are also sometimes also called Bet v 2 proteins.

The lipid transfer proteins in tomato may cause problems if you suffer from LTP Syndrome.

To a lesser extent tomato allergy has been linked to Latex Food Syndrome, which is caused by the body confusing the proteins it encounters in food to that of the profilin proteins found in latex to which it is already sensitised.

Cross Reactivity

If sensitised to birch tree pollen you may have Pollen Food Allergy Syndrome and may also react to apple, kiwi, pear, peach, plum, nectarine, apricots, cherries, potato, celery, carrot, parsnip, pepper, dill, cumin, peas, coriander, fennel, hazelnut, walnut, almonds, peanuts, lentils and beans.

If sensitised to grass pollen you may also react to melon, potato, oranges and peanuts.

Common foods involved in LTP allergy include kiwi, strawberries, sunflower seeds, walnut, apple, mulberry, banana, pea, apricot, cherry, plum, almond, peach pomegranate, raspberry, tomato, grape, celery, peanut, asparagus, cabbage, broccoli, chestnut, lemon, tangerine, orange, hazelnut, lettuce, lentils, lupin, green bean, pear, mustard, wheat and maize.

Other foods containing plant profilins are kiwi, pineapple, celery, peanut, chilli, watermelon, orange, hazelnut, melon, strawberry, soya, barley, walnut, lychee, lupin, apple, banana, date, cherry, almond, peach, pear, mustard, carrot, aubergine and wheat.

The only other foods to contain cyclophilins are peanuts, but the protein has been acknowledged as an airway allergen in mould, birch tree pollen, dust mites, olive tree pollen and magic mushrooms.

Please note that the food lists are not exhaustive, the most up to date data is on the Cross Reactivity Tool.



Allergen Encyclopedia - Tomato

DermNet NZ - Pollen Food Allergy Syndrome

Healthline - Tomato allergies

Tomato Allergy and related Symptoms

Allergy information for: Tomato (Lycopersicon esculentum)

Nightshade Allergy - Aubergine, Potatoes, Pepper & Tomatoes

Histamine - Food List

Sulfite Food List

Healthline - FODMAP Foods

ATP Science - Salicylate Foods

Articles and Journals

Food allergy outside the eight big foods in Europe: A systematic review and meta-analysis, 2024

Safety of yellow/orange tomato extract as a novel food pursuant to Regulation (EU) 2015/2283, 2023

Prevalence of tomato and cucumber sensitization among greenhouse workers, 2022

Tomato Allergy: The Characterization of the Selected Allergens and Antioxidants of Tomato (Solanum lycopersicum) — A Review, 2022

Prevalence of tomato and cucumber sensitization among greenhouse workers, 2021

Novel murine mAbs define specific and cross-reactive epitopes on the latex profilin panallergen Hev b 8, 2020

Dietary Lectins: Gastrointestinal and Immune Effects, 2020

Effect of tomato variety, cultivation, climate and processing on Sola l 4, an allergen from Solanum lycopersicum, 2018

Cross-reactivity syndromes in food allergy, 2013

Tomato allergy: impact of genotype and environmental factors on the biological response, 2011

Allergenic activity of different tomato cultivars in tomato allergic subjects, 2011

Detection of Some Safe Plant-Derived Foods for LTP-Allergic Patients, 2007

Tomato allergy in children and young adults: cross‐reactivity with latex and potato, 2001

Latex allergy: clinical features and cross-reactivity with fruits, 1994

Class I chitinases as potential panallergens involved in the latex-fruit syndrome, 1999

Let me know if you found any of these interesting or useful. If you spot an article or research that you think is interesting you can message me or tag me on Facebook or Twitter - links at the bottom of the page.

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